Side effects, uses, dosage, alternatives, cost, etc.

Zomig can cause mild or severe side effects. The following lists contain some of the main side effects that can occur when taking Zomig. These lists do not include all possible side effects.

For more information about the possible side effects of Zomig, talk to your doctor or pharmacist. They can give you advice on how to deal with side effects that may be concerning or bothersome.

To note: The Food and Drug Administration (FDA) tracks the side effects of drugs it has approved. If you want to notify the FDA about a side effect you have had with Zomig, you can do so through MedWatch.

Mild side effects

Mild side effects* of Zomig nasal spray and tablets may include:

  • feeling cold, heavy, or hot in your body
  • dry mouth
  • nausea
  • numbness or tingling in the arms or legs
  • feel like sleeping
  • stomach ache
  • weakness
  • dizziness†

Other mild side effects reported by people using only Zomig nasal spray include:

  • nose discomfort or irritation
  • increased skin sensitivity to sensations, such as touch or pain
  • sore throat
  • unusual taste

Most of these side effects may disappear within a few days to a few weeks. But if they get worse or don’t go away, talk to your doctor or pharmacist.

*This is a partial list of mild Zomig side effects. To learn about other mild side effects, talk to your doctor or pharmacist, or see the prescribing information for Zomig nasal spray and tablets.
† For more information on this side effect, see “Details of side effects” below.

Serious side effects

Serious side effects from Zomig are not common, but they can occur. Call your doctor right away if you experience any serious side effects. Call 911 or your local emergency number if your symptoms are life-threatening or you think you have a medical emergency.

Serious side effects and their symptoms may include:

  • Bleeding in the brain or stroke. Symptoms may include:
    • difficulty seeing, speaking, or walking
    • weakness in your arm, face, or leg, usually on one side of your body
  • Blood vessel problems, such as vasospasm (sudden narrowing of the arteries). Symptoms vary depending on where in the body the problem occurs, but can include:
    • numbness or weakness in the arms or legs
  • Heart attack. Symptoms may include:
    • severe pain, pressure, or tightness in the chest, which may also affect the jaw, neck, throat, arms, or back
  • Cardiac arrhythmias. Symptoms may include:
  • Medication overuse headache.†
  • Raynaud’s disease (lack of blood flow to the nose, ears, fingers or toes). Symptoms may include:
    • numbness, coldness, or pain in the fingers or toes
    • fingers or toes that turn pale or blue in response to cold or stress, then red when blood flow returns
  • Serotonin syndrome (high level of the chemical serotonin). Symptoms may include:
    • feeling restless or anxious
  • Allergic reaction.*
  • High blood pressure.*
  • Upper body contraction or pressure.*

* For more information on this side effect, see ‘Details of side effects’ below.
† For more information, see “Zomig Withdrawal and Dependence” section below.

Side effects in children

Zomig nasal spray is approved to treat migraine headaches in adults and children 12 years and older. Side effects in children in clinical trials were the same as those reported by adults in trials.

For more information, see the “Mild Side Effects” and “Severe Side Effects” sections above.

To note: Zomig oral tablets and oral disintegrating tablets are approved for use in adults only.

Details of side effects

Here are some details about some side effects that this drug can cause. To find out how often side effects occurred in clinical trials, see Zomig’s prescribing information for nasal sprays and tablets.

High blood pressure

Using Zomig may increase blood pressure. High blood pressure was a reported side effect in clinical trials of the drug.

Most people who have reported this side effect have had very small increases in blood pressure. Generally, high blood pressure does not cause symptoms unless it is severe. And severe high blood pressure is extremely rare with Zomig. However, people with liver problems who have had this side effect have reported large increases in blood pressure in some cases.

Symptoms of severe high blood pressure can include:

  • chest pain
  • confusion
  • nosebleed
  • severe headaches
  • shortness of breath

If you experience any of these symptoms, see your doctor immediately. Or seek emergency medical help if your symptoms seem life-threatening.

While you are taking Zomig your doctor will monitor your blood pressure. They may also suggest that you monitor your blood pressure at home. Talk to your doctor to learn more about how you should monitor your blood pressure.

If you are concerned that you may have high blood pressure while taking Zomig, talk to your doctor. They can discuss your risk for this side effect.

Upper body tightness or pressure

Upper body tightness or pressure was among the most common side effects reported by people who used Zomig in clinical trials. It usually affects the jaw, throat, neck or chest.

In most cases, this side effect is not serious. However, tightness or pressure in the upper body can also be a symptom of more serious side effects, such as a heart attack.

Heart attack rarely occurs with medication. However, you should tell your doctor straight away if you feel any tension or pressure in your upper body while taking Zomig. Or seek emergency medical help if your symptoms seem life-threatening.

Dizziness

Dizziness may occur with Zomig. This side effect was common in clinical trials of the drug.

In most cases, the dizziness is mild and goes away on its own. However, dizziness can also be a symptom of more serious side effects. For example, cardiac arrhythmia, which is a serious side effect of Zomig.

If you have dizziness that doesn’t go away or bothers you, talk to your doctor. They may want to check if this is a symptom of a more serious side effect. They may also recommend trying another medication for your migraine.

Allergic reaction

As with most medicines, some people may have an allergic reaction after taking Zomig.

Symptoms of a mild allergic reaction may include:

A more serious allergic reaction is rare but possible. Symptoms of a severe allergic reaction may include:

  • swelling under the skin, usually in the eyelids, lips, hands, or feet
  • swelling of the tongue, mouth or throat
  • difficulty breathing

Call your doctor right away if you have an allergic reaction to Zomig, as the reaction could become serious. Call 911 or your local emergency number if your symptoms are life-threatening or you think you have a medical emergency.

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