What they are and how to deal with them

If you suffer from migraine, your doctor may suggest Vyepti (eptinezumab-jjmr). Knowing the possible side effects of Vyepti can help you and your doctor decide whether to add it to your treatment plan.

Vyepti is a prescription medication used to prevent migraine episodes in adults. It’s a biologic drug, which means it is made from living cells.

A healthcare professional will give you Vyepti by intravenous (IV) infusion. This is an injection that is given slowly into your vein. You will receive it once every 3 months. Vyepti is generally used long term.

For more information about Vyepti, check out this in-depth article.

Although side effects are not common with Vyepti infusions, some people may experience mild or severe side effects (also called side effects). Keep reading to learn more.

Although side effects from Vyepti are not common, some people may experience them. The most common side effects seen during treatment with Vyepti include:

*For more on this side effect, see the “Side Effects Explained” section below.

The following are examples of mild side effects reported with Vyepti:

*For more on this side effect, see the “Side Effects Explained” section below.

In most cases, these side effects should be temporary. And some can also be easily managed. But if you have symptoms that persist or bother you, talk to your doctor or pharmacist. Do not stop using Vyepti unless your doctor recommends it.

Vyepti may cause mild side effects other than those listed above. See Vyepti’s prescribing information for more details.

To note: After the Food and Drug Administration (FDA) approves a drug, it tracks the drug’s side effects. If you want to tell the FDA about a side effect you had with Vyepti, visit MedWatch.

Serious side effects that have been reported with Vyepti include:

*For more on this side effect, see the “Side Effects Explained” section below.

If you develop serious side effects while taking Vyepti, call your doctor right away. If the side effects seem to be life threatening or you think you have a medical emergency, call 911 or your local emergency number immediately.

Get answers to some frequently asked questions about Vyepti side effects.

Does Vyepti make you gain weight?

No. Weight gain was not reported in studies with Vyepti, which lasted up to 12 months.

If you have any questions about weight gain since starting treatment with Vyepti, talk to your doctor. They can help you identify other causes and recommend ways to maintain a moderate weight.

Can Vyepti cause anaphylaxis?

It’s possible. Anaphylaxis did not occur in people who received Vyepti in the studies. But this serious type of allergic reaction is possible with any medication.

There have been reports of this side effect in people using Vyepti. But it is not known how many times this happened or if Vyepti was the cause.

A healthcare professional will give you Vyepti as an intravenous (IV) infusion at a doctor’s office or clinic. If you start having symptoms of an allergic reaction during an infusion, they will stop the infusion. They will likely treat your symptoms as well.

Is it painful to receive an infusion of Vyepti?

Vyepti is given as an IV infusion, which is an injection into your vein given over a period of time. As with any injection, you may feel a very quick “pinch” of pain when a healthcare professional inserts the needle.

Vyepti infusions are given over 30 minutes. You should not feel any pain during the infusion.

What are the long-term side effects of Vyepti treatment?

So far, no long-term side effects have been reported with Vyepti in studies of the drug. (Vyepti studies lasted up to 12 months.) No long-term side effects have been reported since the drug became available on the market.

If you have any questions about the long-term side effects of Vyepti, talk to your doctor. They can help you weigh the pros and cons to determine if the drug is right for you.

Learn more about some of the side effects Vyepti can cause.

Nose or throat symptoms

Nasopharyngitis (irritation of the nose or throat) is a possible side effect of Vyepti treatment. Nasopharyngitis is another name for a cold.

In studies of Vyepti, people took 100 milligrams (mg) of the drug, 300 mg of the drug, or a placebo. (A placebo is a treatment that does not contain any active drug.)

Nose or throat symptoms were also common in people given 100 mg of Vyepti or the placebo. These symptoms occurred slightly more often in people who received 300 mg of Vyepti than in those who received 100 mg or a placebo.

Cold symptoms include:

What might help

Cold symptoms usually go away on their own without treatment. It is often helpful to rest more and drink more fluids.

To relieve nose or throat symptoms, consider over-the-counter (OTC) remedies. These may include:

If your nose or throat symptoms do not go away or become bothersome, talk to your doctor. They may want to check for other causes or recommend other treatments.

Allergic reaction

Like most medicines, Vyepti can cause an allergic reaction in some people.

Symptoms can be mild or severe and can include:

  • itchy skin
  • itching
  • hot flashes (temporary warmth, redness or deepening of skin color)
  • swelling under the skin, usually in the eyelids, lips, hands, or feet
  • swelling of the mouth, tongue, or throat, which may make it difficult to breathe

What might help

If you have mild symptoms of an allergic reaction, such as a mild rash, tell your doctor right away. To manage symptoms, they may suggest an over-the-counter antihistamine that you take by mouth, such as Benadryl (diphenhydramine). Or they may recommend a product that you apply to your skin, such as hydrocortisone cream.

If your doctor confirms that you have had a mild allergic reaction to Vyepti, they will decide whether you should continue to use it.

If you have symptoms of a serious allergic reaction, such as swelling or difficulty breathing, call 911 or your local emergency number immediately. These symptoms can be life-threatening and require immediate medical attention.

If your doctor confirms that you had a serious allergic reaction to Vyepti, they may switch you to another treatment.

Side Effect Tracking

During your Vyepti treatment, remember to take notes about any side effects you experience. Then you can share this information with your doctor. This is especially helpful when you start taking new medications or using a combination of treatments.

Your side effect notes may include things like:

  • what dose of the medicine you were taking when you had the side effect
  • how long after starting this dose you had the side effect
  • what were your symptoms of the side effect
  • how it affected your daily activities
  • what other medications you were also taking
  • any other information you consider important

Keeping notes and sharing them with your doctor will help your doctor learn more about how Vyepti affects you. And your doctor can use this information to adjust your treatment plan if necessary.

Vyepti may not be right for you if you have certain medical conditions or other factors that affect your health. Talk to your doctor about your medical history before you start receiving Vyepti. Below are the factors to consider.

Allergic reaction. If you’ve had an allergic reaction to Vyepti or any of its ingredients, your doctor probably won’t prescribe Vyepti for you. Ask your doctor what other medications are better options for you.

Alcohol consumption and Vyepti

Vyepti does not interact with alcohol.

But drinking alcohol can trigger migraine symptoms in some people. Even though Vyepti is used to prevent migraine episodes, it’s a good idea to continue to avoid or limit the things that trigger them.

If you have any questions about drinking alcohol while taking Vyepti, talk to your doctor.

Pregnancy and breastfeeding while receiving Vyepti

It is not known if Vyepti is safe to use during pregnancy. The drug has not been studied in pregnancy.

It is also not known if Vyepti is safe to use while breastfeeding. The studies did not look at whether Vyepti treatment had any effects on breast milk or a breastfed child.

If you are pregnant or breastfeeding, or planning to become pregnant or breastfeeding, talk to your doctor. They can guide you on how to safely manage migraine during these times.

Side effects are not common when receiving Vyepti, but mild or severe side effects are possible.

If you are curious about the side effects of Vyepti, talk to your doctor or pharmacist. Ask questions to get the answers you need to start treatment with confidence to prevent migraine episodes. Here are a few to help you get started:

  • Do my other medications increase my risk of side effects from Vyepti?
  • Does receiving a higher dose of Vyepti (300 milligrams) cause more side effects than a lower dose?
  • I have heart disease. Am I at higher risk for side effects from Vyepti?

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Warning: Healthline has made every effort to ensure that all information is factually correct, complete and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or for all specific uses.

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