Study: Triptans Provide Best Pain Relief For Migraines, But Have More Side Effects Than Newer Drugs

October 11 (UPI) – A class of drugs called triptans remains the most effective treatment for migraines, according to an analysis of data from more than 60 studies published Monday by the JAMA Network Open.

Adults treated with a triptan were up to three times more likely to report no pain two hours later than those given the migraine medication lasmiditan, sold under the name Reyvow; rimegepant, brand Nurtec ODT; or ubrogepant, under the brand Ubrelvy, showed the data.

However, the newer drugs – in classes of drugs called gepants and ditans – appear to have fewer side effects and may be safer for people with a history of heart disease or stroke, they said.

“The newer drugs for the treatment of acute migraine, gepants or ditans, are effective compared to placebo, but they are not as effective as triptans, the standard drug currently prescribed for acute migraine,” said UPI study co-author Dr. Shuu-Jiun Wang. E-mail.

“Nevertheless, gépants and ditans are safe for people with cardiovascular risks, and gépants have a much lower rate of adverse events” compared to triptans, said Wang, neurologist at Alumni General Hospital. fighters from Taipei to Taiwan.

According to the American Migraine Foundation, triptans such as sumatriptan or Imitrex, naratriptan or Amerge, and zolmitriptan or Zomig have been used for years to relieve the pain of acute migraines or severe headaches.

However, the drugs don’t work for all people with migraine and can lead to serious health complications in people with a history of heart disease or stroke, according to the foundation.

The new options mitigate some of these health risks, but they may not be as effective as older drugs, Wang said.

Either way, the triptans outperformed the newer drugs in terms of pain relief, the data showed.

However, rimegepant and ubrogepant were both safer for people with a history of heart disease or stroke, and generally had fewer side effects than triptans, the researchers said.

Common side effects of triptans include nausea, rapid heart rate, fatigue, numbness, and a burning sensation on the skin, according to the American Migraine Foundation.

“These new drugs provide more choices for migraine patients,” Wang said.


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