Side Effects, Uses, Cost & More

Like most medicines, Reyvow can cause mild to severe side effects. The lists below describe some of the more common side effects that Reyvow can cause. These lists do not include all possible side effects.

Keep in mind that the side effects of a medicine can depend on:

Your doctor or pharmacist can tell you more about the potential side effects of Reyvow. They can also suggest ways to help reduce side effects.

Mild side effects

Here is a short list of some of the mild side effects that Reyvow can cause. For more information about other mild side effects, talk to your doctor or pharmacist, or read Reyvow’s medication guide.

Mild Reyvow side effects that have been reported include:

Mild side effects of many medications may disappear within days or weeks. But if they become bothersome, talk to your doctor or pharmacist.

*For more information on this side effect, see the “Side Effects Focus” section below.

Serious side effects

Serious Reyvow side effects can occur, but they are not common. If you have serious side effects from Reyvow, call your doctor right away. But if you think you have a medical emergency, call 911 or your local emergency number.

Serious side effects of Reyvow that have been reported include:

*For more information on this side effect, see the “Side Effects Focus” section below.

Focus on side effects

Learn more about some of the side effects Reyvow can cause.


Due to how Reyvow works, it may make you dizzy. In studies, dizziness was the most commonly reported side effect in people taking Reyvow. This side effect was even more common in people who took higher doses of the drug.

Dizziness may occur more often in people aged 65 and over. Dizziness can lead to falls or serious injuries such as broken bones.

What might help

After taking a dose of Reyvow, it may help to sit or lie down for a while. You may not feel dizzy while resting or napping.

Since Reyvow can cause dizziness and drowsiness, you should not drive for at least 8 hours after taking your dose.

If you develop bothersome dizziness with Reyvow, tell your doctor. They may suggest a lower dose or another treatment option. And they will determine if there are ways to help reduce your dizziness.

Feel like sleeping

Reyvow can make you sleepy. This has been reported as a common side effect in studies.

You should not take Reyvow unless you can avoid driving for the next 8 hours. Even if you don’t feel sleepy, the medicine may make you less alert for up to 8 hours.

What might help

It may not be possible to prevent drowsiness after taking Reyvow. It is a good idea to lie down and rest after taking the medication, if you are able.

If you take Reyvow with other medicines or substances that cause drowsiness, it may make this side effect worse. Before taking other medicines with Reyvow, consult your doctor or pharmacist.

Rebound headaches

It is possible to get rebound headaches (also known as medication overuse headaches) while you are taking Reyvow. Rebound headaches occur when headaches are treated with too many painkillers, get worse, and occur more often.

Reyvow is a medicine used to treat a migraine episode while it is happening. But taking Reyvow 10 or more days each month can cause rebound headaches in some people.

Rebound headaches can also occur with other medications used to treat migraine episodes while they are occurring. Some examples include triptans, opioids, over-the-counter pain relievers, or a combination of these.

What might help

You can help prevent rebound headaches by taking Reyvow less than 10 days per month. In fact, taking more than four doses of Reyvow in 30 days may not be safe. If you feel you need to take more than four doses within 30 days, talk to your doctor.

If you get rebound headaches with Reyvow, your doctor will likely suggest that you stop taking the medicine. This may cause your headaches to return temporarily.

To avoid taking Reyvow too often, use a calendar to track the days you take it for migraine episodes.

Allergic reaction

Some people may have an allergic reaction to Reyvow.

Symptoms of a mild allergic reaction may include:

  • itchy skin
  • sun sensitivity
  • itching
  • hot flashes (temporary warmth, redness or deepening of skin color)

A more serious allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include swelling under the skin, usually on the eyelids, lips, hands or feet. They can also include swelling of the tongue, mouth, or throat, which can lead to difficulty breathing.

Call your doctor right away if you have an allergic reaction to Reyvow. But if you think you have a medical emergency, call 911 or your local emergency number.

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